Gene information
Official symbol ANGPT2
Official full name angiopoietin 2
Gene type protein-coding gene
Chromosome8p23.1
Alias symbolAng2
Gene familyReceptor ligands; Fibrinogen C domain containing
Resources
Entrez Gene 285
HGNC HGNC:485
Ensembl ENSG00000091879
Vega OTTHUMG00000090365
UCSC uc003wqj.6
GO terms: 57 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007276 gamete generation GO Biological Processes -2.03816629 18 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010812 negative regulation of cell-substrate adhesion GO Biological Processes -8.89322529 17 More
GO:0014823 response to activity GO Biological Processes -19.5783025 27 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030971 receptor tyrosine kinase binding GO Molecular Functions -4.12949610 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032835 glomerulus development GO Biological Processes -5.62617381 12 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0060135 maternal process involved in female pregnancy GO Biological Processes -5.36863544 12 More
GO:0061437 renal system vasculature development GO Biological Processes -6.91942497 9 More
GO:0061440 kidney vasculature development GO Biological Processes -6.91942497 9 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072006 nephron development GO Biological Processes -8.44009723 23 More
GO:0072012 glomerulus vasculature development GO Biological Processes -7.35783353 9 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1990782 protein tyrosine kinase binding GO Molecular Functions -4.10270724 15 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
Drug-Gene interaction
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Related drugs: 4 records
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
angiopoietin-2 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Iribarren C et al. BMC Cardiovasc Disord. 2011
angiopoietin-2 proteomics myocardial injury[prognosis (bad)] acute ST elevation myocardial infarction Chen S et al. Biomarkers. 2012
angiopoietin-2 proteomics heart failure[prognosis (bad)] acute ST elevation myocardial infarction Chen S et al. Exp Ther Med. 2013
angiopoietin-2 proteomics medium predictor acute kidney failure[prognosis (bad)] acute myocardial infarction Liu KL et al. Crit Care. 2014
angiopoietin-2 proteomics death[prognosis (bad)] acute myocardial infarction Poss J et al. Eur J Heart Fail. 2015
angiopoietin-2 proteomics death[prognosis (bad)] acute myocardial infarction Poss J et al. Eur J Heart Fail. 2015
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